When your child has a fever, research suggests both acetaminophen and ibuprofen work about equally well to bring down temperature and help your child feel more comfortable. Studies indicate that ibuprofen might bring the fever down slightly faster, but the difference is so small it probably won't matter in practice. The real takeaway? Pick whichever one you have on hand and can give your child safely. What matters most is following the correct dose for your child's age and weight — ask your pediatrician or pharmacist to walk you through dosing before you leave, since research shows many parents struggle with measuring accurately. Don't mix the two medicines together. Focus on comfort and hydration, and give medicine only when your child seems uncomfortable, not automatically.